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About Biffy

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  1. You said some time ago that unrefined Sunflower oil is anti-dht and pro-health? My main concern is storage of these unrefined PUFA oils, they can turn toxic with just little amount of oxygen or light...
  2. Peatarin view on some hugely popular natural supplements. Full article: To sum it up: Curcumin The study below shows that it may stress the body causing it to create MORE thyroid hormone in youth, when the body still possesses the youthful ability to do so in response to stress. However, as the organism ages, levels free thyroid hormone T3 dropped significantly. Resveratrol The study below shows that reserveratrol does interfere with thyroid activity, and increases TSH while decreasing both T4 and T3 for a double-negative effect. It also decreased thyroid perixodase (TPO) activity which is responsible for breaking off iodine for combination with tyrosine for production of thyroid hormones T3 and T4. In a recent study, to determine whether resveratrol would slow the heart rate and lower the body temperature in mice, those metabolic indicators were depressed by resveratrol for one day, but then returned to normal. The endurance of the mice on a treadmill was reduced by the resveratrol treatment (Mayers, et al., 2009). This sounds similar to Gilbert Ling’s frog that’s heartbeat never returned to original strength after a spell of living with a depressed metabolism. Carnitine It is marketed as a fat loss supplement because it increases lipolysis (the conversion of fat to sugar). While that does sound good for weight loss, using fat for energy is very inefficient and hard on the body, and makes you prone to storing more food as fat as it represents a primitive, slow metabolism. The people who have written extensively about it being good have experienced adrenaline highs. They may not have experienced adrenaline lows (where tissue is no longer sensitive to adrenaline) yet, but they will. All fatty acids are deficient in oxygen (two oxygen atoms per molecule) so using them for energy automatically creates more lactic acid than CO2. CO2 is produced in greater amounts by the use of sugar (typically six or more oxygen atoms per molecule depending on the saccharide size) for energy. In addition, carnitine may negatively affect the transport of T3 and T4 into cells – which makes sense as fatty acid metabolism and free fatty acids inhibits glucose metabolism by reducing insulin sensitivity, L-carnitine has been found to act as a peripheral antagonist of thyroid hormone action. In particular, L-carnitine inhibits both triiodothyronine (T3) and thyroxine (T4) entry into the cell nuclei. Paradoxically, children with carnitine deficiency may have increased free fatty acid concentrations and hypoglycemia. This makes sense if you understand that carnitine transports fatty acids into cells for energy production. The key is to not have high free fatty acids to begin with by making sugar a principle part of your diet to suppress adrenaline and ensuring you have adequate levels of vitamin B3 (niacinamide). The reduction of free fatty acids will increase your glucose sensitivity and improve your metabolism without use of carnitine. Relying on fatty acid metabolism and carnitine for energy production can negatively affect bones, which require continuous reconstructive and efficient metabolic functions of osteoblasts for maintenance of bone mass. Fish Oil High doses of fish oil might also reduce the immune system’s activity, reducing the body’s ability to fight infection. This is a special concern for people taking medications to reduce their immune system’s activity (organ transplant patients, for example) and the elderly. Indeed, in a study done on mice attempting to prove the anti-inflammatory and immune supporting effects, researches found the mice were more susceptible to induced bacterial infections following high doses of fish oil. About the cytoxicity of Resveratrol and Curcumin I do think these substances are only cytotoxic, when needed (cancer, bacteria). What do you think, is the thyroid lowering effect something of concern?
  3. I have noticed a lot of people after the age of 50 get colon and bladder cancer. Here in our country this group is included in a prevention program for check-ups, if they have blood in their fecal samples. I wonder why the doctors don't test for hormones and vitamin D status - it is evident that they play significant role, with these tests we could prevent most of colon and bladder cancers. Instead we have a program for 50-74 old men that includes rectal and colon examination...not particularly pleasant.
  4. 15. Starches are extremely insulinogenic, they raise you insulin response a lot more than sugar, so you better of with eating easily digestible simple carbohydrates like ripe fruits, sugar and "safe" starches like white bread, white rice and very well cooked potatoes, to prevent endotoxin and serotonin response.
  5. I've found some more of their controversial stances, help me out with this: 11. Probiotics and fermented foods are bad for you, because they contain Lactobacillus, which then convert to lactic acid and the raise in this acid is implicated in all major auto-immune diseases, like in cancer. Lactobacillus casei. species are especially bad - in one study it was shown that can cause auto-immune disease called Lupus. Also beneficial bacteria can trigger multiple sclerosis, you can see the explanation for this on Ray Peat forum thread... If you keep your gut sterile you don't develop autoimmunity like for example babies, this is one of the reasons they suggest the use of antibiotics, besides antibiotics effect on lowering of serotonin, endotoxin and nitric oxide. Two examples, people with Lyme disease put on antibiotics improve their symptoms, animals put on antibiotics have incredibly little incidence of cardiovascular diseases. Countries that have highest rate of fermented foods consumption, have the highest incidence of colon cancer.They say ALL probiotics won't even work cause they don't get to the colon. 12. HDL is bad so you should keep it low as possible and LDL is actually preferred to be higher, they say LDL is only good cholesterol. Interestingly more and more research is emerging that confirm high HDL values equal increased risk of cardiovascular disease. They say all of the substances that raise HDL are toxic and the body raises it in response, for example HDL is raised with ethanol, ionizing radiation, excessive exercise, estrogen, fish oil. 13. It is better to eat refined grains as oppose to difficult to process whole grains, because that kind of grains pass through mall intestine and make it in large intestine where bacteria feed on them and generate a lot of endotoxin. This one is really interesting. 14. You need to keep phosphate levels as low as possible, and keep high calcium to phosphate ratio. Inorganic phosphate in itself is turning out to be very central for all metabolic processes. High phosphate inhibits parathyroid hormone. Meat, grains and beans are high in phosphate so you should avoid excess and drink lots of milk, cuz it contains low phosphate and high calcium content.
  6. I found this FB page some time ago, but thanks nevertheless. I am registered to many GcMAF facebook groups and one of the administrators is saying the most legit GcMAF actually comes from Japan (Saisei Mirai) and not this Swiss First Immune company (First Immune). What she said about the strength of the product: "The injections from Japan are stronger than the goleic sold by first immune, so you are getting more for your money. In cancer, higher doses work better." I dunno if this is true, but she seems to have huge knowledge about the quality of the GcMAF. Now there is actually new third generation GcMAF in capsules (from Germany called GC Immune Forte) that doesn't need to be injected, but I am extremely sceptical about it, as it doesn't really contain real human GcMAF just some probiotics strains, fermented milk peptides and bovine colostrum. Need to see if this product really decreases nagalase levels, in one study it did increase natural killer cells by 300%.
  7. They actually think of themselves as open minded to different ideas and interpretations.They oppose authoritarianism on every field of human life and encourage people to do their own research and come to their own conclusions. I was probably to harsh to them in my first post with the head in the sand reference. Still Peatarians have this problem that they try desperately to find studies that prove their view and ignore the ones that discard their view on human health. Maybe they think they are cool cause they oppose other more "mainstream" alternative health authorities I dunno. While sometimes they forget the complexity of human body and the hormones and their interplay, like with seratonin. Still most of their views make a lot of sense, a lot more than pharma theories haha .
  8. What is your opinion on treating cancer with GcMAF and GOLEIC? Anyone has experience or know GcMAF cancer survivors? What are some good supplements to use with this?
  9. So I have done a “compilation” of simplistic rationale on what topics did Ray Peat and his followers got it all wrong: 1. Omega-3 should be avoided, cuz they are PUFA – they ignore enormous positive data on health benefits of krill and fish oil, they ignore PGD2 lowering effects, they say that positive results from people supplementing omega-3 is just a placebo effect :). 2. All PUFA should be avoided, including raw nuts – similarly they ignore all the positive effects of unprocessed LA and GLA on human health, especially PGE1 increase, fluidity of the cells and for MPB the 5AR lowering effect. 3. Iodine is dangerous and should be avoided, so you should use thyroid hormones like Cytomel instead – experience of people and the work of David Brownstein puts this practice to shame. 4. You need to add more Calcium to your diet, it will vastly benefit your health – our diets are rich enough in calcium, the problem occurs because of mishandled calcium. 5. Insulin resistance is not caused by over consumption of sugar, but because of the free fatty acids floating around – it may be that this free fatty acids are the driving force behind it, but they are subjected to oxidation only when there is an abundance of sugar. All in all I don't think you can avoid fatty acids with diet modifications, so you better to ingest some antioxidants. 6. Aspirin is safe to use long term – there are many studies on toxicity of long term Aspirin. 7. Caffeine with sugar is appropriate for everyone – if one has existing adrenal fatigue or gastrointestinal distress, daily caffeine will deplete your adrenals even more and cause you more problems long term. 8. Aspirin, Caffeine, Gelatin, Niancinamide, Taurine will make a difference in MPB – in theory they have some value, but practically all of this compounds simply didn’t provide any real difference for MPB based on current studies, there is frankly little to no benefits and imo anecdotal reports confirm this. There are much better and efficient supplements to treat MPB. 9. Serotonin is unambiguously bad for you, so you should at all cost avoid all the high serotonin foods and supplements – I think it the main point here is that both low serotonin and high serotonin aren’t good for you, the balance is the key here. 10. Using sugar is the best way to lower heightened cortisol and support your thyroid function – you don’t need to ingest sugar to lower cortisol, you can ingest starch to turn into glucose in the body and lower cortisol rise or take appropriate supps. Actually sugar increases adrenaline, not decreases like they say, so in the long term you pay with longevity. I think there are other factors more important in thyroid health than sugar consumption, if you do keto diet then there may be thyroid problems. Please correct me on any of this points if I’m doing them disservice. Where they got it right: Coconut oil, Vitamin K2, Vitamin A, Vitamin D, Orange Juice, Red Light, Carbs and also refined sugars are not bad per se (imo this is true if one has optimal metabolic and thyroid function), Endorsing safe starches like potatoes and rice, Estrogen-low progesterone-high cortisol-high prolactin-thyroid issues are the driving force behind MPB not Testosterone or DHT, Salt and even sodium is good for you. It is really awkward that such scientific minded and knowledgeable, intelligent, well researched people got it so wrong on so many nutrition and health aspects. They are so confident in their made up theories it’s crazy, they talk like they have everything figured it out, they laugh at people who take omega-3 like they are nut jobs. They ignore all the stuff that could potentially harm their theories – basically have their heads in the sand. If you have any more misinformation’s from Ray Peat and his Peatarian army please share, I don’t want to mock their work, frankly I am intrigued in studying their views because they go in the opposite direction of all other health gurus. Only time will tell who is right.
  10. Do you think using Colostrum on top of Ecklonia will improve my hair further or it is just unnecessary gamble - I don't won't to overdo IGF-1. I am suspecting that IGF-1 is a major problem for me because no DHT blocker ever worked for me, I also have thin hair all over my head (especially on the sides) not just in MPB pattern area.
  11. What if vegetable oil like rapeseed oil is unprocessed extra-virgin (cold-pressed) without hexane, does it also have high androgen activity and other bad effects on human health? I get that the storage is a big issue, but in that case all the oils are problematic even olive oil etc. I was at the supermarket today and I am seeing a lot of processed products like energy bars, chips and wafers that changed their formula and now contain palm oil. Palm oil is undoubtedly more healthy than other classic vegetable oils, but I doubt the manufacturers use quality unrefined palm oil. So basically the palm oil is also produced in "traditional chemical way" or for refining palm oil use more "natural" approach? Also palm oil seems to be even more prone to oxidation if you expose it to high temperatures, so basically is just a matter of picking your poison.
  12. There are a lot of mixed opinions on best cooking oil some experts say coconut, some say avocado oil, some palm oil. The reality is the canola and sunflower oil are the most stable even at high temperatures, so they seems ideal for frying, maybe if we used extra virgin sunflower or rapeseed it would be ok. Avocado oil seems like a best bet as there is no cholesterol in avocado oil, so oxidized cholesterols are not an issue. What about oilve oil which is also cholesterol free, but there are some mixed opinions on this one? Also based on article bellow saturated fats are a no-no when it comes to cooking. Generally I avoid vegetable oils like rapeseed oil a plaque, due to 5ar raising, but it seems they have some positive effect on human body: Some interesting quotes from this article: "Using high MUFA rapeseed oil not just for frying, but as a major fat source in the diet leads to significant improvements in blood lipids in hypercholesterolaemic subjects (Gillingham. 2011)" " You cannot seriously be suggesting sunflower and canola oil! Yes, I can! I know that both have quite a bad reputation, but if you look at the scientific evidence that's mostly unwarranted. If you look objectively at the existing evidence, it is debatable whether this may not be superior to using olive oil or other high MUFA oils, but certainly superior to using other frying oils or animal fats. Plus: It works it cholesterol lowering and glucose metabolism improving magic not just in patients with high cholesterol levels (see figure on the left), but also in healthy young women (Uusitupa. 1994; Jones. 2014). " " In a similar vein, canola aka eruchic acid free rapeseed oil, which is also available as high oleic acid cooking oil, has been shown to reduce TC concentrations in healthy or hypercholesterolemic individuals, compared with high-SFA or typical Western diets. Studies also indicate that it "may potentially promote immune and cardiovascular health through its antithrombic and antioxidative effect" (Lin. 2013). For the other benefits listed in the overview in Figure 4, the results are sometimes less equivocal. Overall, Lin et al. whose review of literature was obviously funded by the canola industry still claims that "canola oil can now be regarded as one of the healthiest edible vegetable oils in terms of its biological functions and its ability to aid in reducing disease-related risk factors and improving health" (Lin. 2013) - a claim that sounds a bit hyperbolic, in spite of the fact that their review of the literature supports many of the claims. " "If you look closely at the time and heat it takes for the bad byproducts of cooking and frying to arise, it is evident that it's not you, but rather the food industry and restaurants with their high temperatures and cooking times that are to blame for the problems. They are the ones using the "discontinuous frying process" of which Dobarganes and Márquez-Ruiz say that only they allow frying oils to reach "degradation levels much higher than that established for human consumption" (Dobarganes. 2015)." " If you are frying your foods at home, use oils with high amounts of unsaturated fast like virgin olive oil (or alternatives for longer frying durations and higher temperatures) and don't start frying snickers or ice-cream (as seen on TV ;-), frying your foods may actually be way less hazardous than many of you probably thought. " " Unfortunately, there are other problems with ghee; problems that are related to the heat-induced oxidation of cholesterol and the presence of large amounts of cholesterol oxides in commercially available "clarified butter" even before you even start heating it as it was reported by Kubow et al. in 1993 (12.3% w/w of total sterols)." "Needless to say that neither tallow nor lard or any other of these animal fats contain enough antioxidants to protect their cholesterol from being oxidized (Ryan. 1981; Park. 1986a,b). Interestingly, Park et al. have been able to show that this process starts at temperatures as low as 135°C (the recommended frying temperature for most products is 160°C+) and does not increase with higher temperatures. For pure cholesterol Osada et al. determined 120°C as the lowest temperature that induces oxidative changes (Osada. 1993). In 1986, a group of researchers who conducted research for the French government found that 78% of the total cholesterol that was lost (23% of total cholesterol) from beef tallow during deep frying was recovered in form of the four best known forms of oxidized cholesterol, i.e. Triol-, 7a-, 7/3-, and 7-Oxo-cholesterol (Bascoul. 1986). "
  13. UPDATE: She was misdiagnosed with lymphocytic leukemia, later they found out that she has another autoimmune disorder called Sjorgen's Syndrome. Are there any good natural supplements and general diet guidelines for this? What I found as of now is Krill oil, Green Tea Extract, Vitamin D, B-Vitamins, DHEA (via Magnesium oil), heavy metal detox...
  14. Well this goes in the opposite way of what is touted on internet by holistic medicine practitioners including respectable sites like Truth about Cancer and Cancer Tutor. Some rather convincing statements are made here and the author seems confident about them like: " The claims on the internet that chemotherapy is “only 3 per cent effective” are highly misleading and outdated, and are explored in more depth in these two posts from the Science Based Medicine blog. " "Proponents of this theory say that cancer is caused by infection by the fungus candida, and that tumours are actually the body’s attempt at protecting itself from this infection. But there’s no evidence to show that this is true (and plenty of evidence – going back at least as far as 1902 – that it starts from faults our own cells). " "The ‘simple solution’ is apparently to inject tumours with baking soda (sodium bicarbonate). This isn’t even the treatment used to treat proven fungal infections, let alone cancer. On the contrary, there’s good evidence that high doses of sodium bicarbonate can lead to serious – even fatal – consequences." " As far as we are aware, there have been no published clinical trials of sodium bicarbonate as a treatment for cancer. " "But all this doesn’t mean that sugar from cakes, sweets and other sugary foods specifically feeds cancer cells, as opposed to any other type of carbohydrate. Our body doesn’t pick and choose which cells get what fuel. It converts pretty much all the carbs we eat to glucose, fructose and other simple sugars, and they get taken up by tissues when they need energy." " But there’s no good evidence to prove that diet can manipulate whole body pH, or that it has an impact on cancer. We’ve also written extensively on the scientific evidence about anti-oxidants and cancer in these posts – part one, part two and part three. [Added 28/03/14 KA] The steady accumulation of evidence over several decades points to a simple, but not very newsworthy fact that the best way to reduce your risk of cancer is by a series of long-term healthy behaviours such as not smoking, keeping active, keeping a healthy body weight and cutting back on alcohol." "While it’s certainly true that global lifestyle-related diseases like cancer are on the rise, the biggest risk factor for cancer is age."